Abstract
Endoscopic treatment to eliminate Barrett’s Oesophagus, associated dysplasia and intramucosal cancer, in order to induce squamous re-epithelialisation has been developed as a viable, oesophagus-sparing alternative for eligible patients in recent years. It has gained popularity given its less invasive nature and better tolerability relative to radical oesophagectomy. Widely used modalities include endoscopic mucosal resection, radiofrequency ablation, argon plasma coagulation, photodynamic therapy and cryotherapy, each having their own advantages and limitations. Yet invasion of dysplasia into and beyond the submucosal layer of epithelium signifies potential metastasis, rendering endoscopic intervention no longer appropriate, and surgical intervention remains the definitive treatment. This review highlights the disease process of Barrett’s Oesophagus and associated dysplasia and early cancer, the various treatment options and appropriate selection of patients, indications and management considerations.